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CRU Organization
Dean, Faculty of Tropical Medicine
Chief, Clinical Trial Project
Staffs
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CRU Organization 2006 > About VTC > Phase I, II and III HIV-1 vaccine trials in the VTC
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Phase I, II and III HIV-1 vaccine trials in the VTC
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Vaccine |
Vaccine |
Phase |
No of participants |
Dose interval |
Type of immunity |
Subunit
(recom- binant protein)
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1995
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I/II |
33 recovering IDUs
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0, 1, 6 and 12 months
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Humoral |
gp120/MF59, subtype E antigen alone or combined with B antigen
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1997
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I/II |
370 low risk adults (99-VTC)
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0, 1, and 6 months |
Humoral |
gp120/alum, combined subtype B (AIDSVAX B/E)
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1998
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I/II |
92 recovering IDUs and low risk adults
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0, 1, 6 and 12 months |
Humoral |
r gp120/alum, combined subtype B (AIDSVAX B/E)
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1999
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III |
2,500 high risk IDUs
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0, 1, 6, 12, 18, 24 and 30 months |
Humoral |
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ALVAC-HIV rgp 120 B/E boost
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2000
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I/II |
123 low risk adults (62-VTC)
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0, 1, 3 and 6 months
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Cell mediated + humoral |
ALVAC-HIV rgp 120 B/E boost
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2003
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III |
16,000 low risk adults
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0, 4, 12 and 24 weeks |
Cell mediated + humoral |
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2003
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I/II |
87 healthy adults (29-VTC)
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0, 4 and 26 weeks |
Cell mediated + humoral |
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To date, seven projects of phase I/II and phase III HIV-1 vaccine trials, involving thousands of volunteers, have been conducted by the Center, or as one of the collaborators.
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